Antibodies, hold the light chain
نویسندگان
چکیده
منابع مشابه
Application Note ► Purifying common light-chain bispecific antibodies using MCSGP
In this application note the purification of a common light-chain bispecific antibody using Multicolumn countercurrent solvent gradient purification (MCSGP) is described. The KNAUER Contichrom® system that is offered in cooperation of KNAUER and Chromacon is the only system on the market that can be used in MCSGP mode for difficult bioseparations. MCSGP is a countercurrent chromatographic proce...
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Since the discovery of antibody-producing B cells in chickens six decades ago, chickens have been a model for B-cell development in gut-associated lymphoid tissue species. Here we describe targeting of the immunoglobulin light chain locus by homologous recombination in chicken primordial germ cells (PGCs) and generation of VJCL knockout chickens. In contrast to immunoglobulin heavy chain knocko...
متن کاملHeavy chain–only antibodies are spontaneously produced in light chain–deficient mice
In healthy mammals, maturation of B cells expressing heavy (H) chain immunoglobulin (Ig) without light (L) chain is prevented by chaperone association of the H chain in the endoplasmic reticulum. Camelids are an exception, expressing homodimeric IgGs, an antibody type that to date has not been found in mice or humans. In camelids, immunization with viral epitopes generates high affinity H chain...
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This paper shows that the commutativity condition [A(t), A′(t)] = 0 is often not necessary to guarantee the chain rules for matrix functions: d dtf(A(t)) = A ′(t)f ′(A(t)) and d dtf(A(t)) = f ′(A(t))A′(t), where A(t) is a square matrix of differentiable functions and f is an analytic function. A further question on the chain rules is presented and discussed.
متن کاملAntibodies against the light chain of tetanus toxin in human sera.
Tetanus toxoid elicits protective antibodies against tetanus toxin in humans and animals. It has been reported that antitoxin from immunized humans contains no anti-light chain antibodies, based on immunodiffusion and quantitative precipitin analyses. We confirmed the absence of precipitating anti-light chain antibodies in tetanus immune globulin. However, the presence of antibodies against the...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2007
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20413iti4